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The exponential growth in pharma industry had lead to development of life saving drugs. To ensure highly safe medicines reach patients, industry places many quality checks. Development of accurate and validated method is one such measure. An accurate analytical method was developed for the assay of lamotrigine in pharmaceutical-formulations. It is a drug which is used for treatment for epilepsy. The method involves Grace-C18 column and mobile phase composition of 50:50, v/v of phosphate buffer and methanol. The wavelength of detection is 308nm. The proposed method can be used for quality estimation of drug in pharmaceutical formulations.
The present research is based chromatographic technique which the author has developed, an alternative to traditional methods. This method evaluates the purity and safety of the lamotrigine tablets available in the market. The method developed is highly specific and free from interference of excepients. The reported method is less cumbersome, adaptable to quality control laboratories. The method under study is successfully validated as per ICH quality guideline. The reported method is reproducible and accurate (99.5-100%), reported time period of the method is less than 10 minutes. The kinetic behaviour of lamotrigine under different conditions of degradation study was evaluated.

Journal Name: International Journal of Pharmacy and Technology , Volume Number: 4(1) , Page Number: 3843 ,
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Bavirisetty Venkata Kiran Says

goody On 2017-07-30 09:5

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